PARIS, France — Lab checks during which aged mice have been injected with a protein present in human umbilical wire blood have thrown up an intriguing goal for preserving the mind wholesome into older age, scientists mentioned Wednesday.
The protein of curiosity, TIMP2, has beforehand been discovered to play a task in creating the hippocampus — the a part of the mind that permits spatial navigation and processes recollections.
TIMP2 is plentiful within the plasma of umbilical cords, however ranges of it decline with age.
A group led by Tony Wyss-Coray at Stanford University in California injected ageing mice with TIMP2.
The injections boosted exercise within the rodents’ hippocampus, and their studying, reminiscence and talent to adapt to new info all improved, notably of their skill to extract themselves from a lab maze.
TIMP2 — or the mind cells that the protein acts upon — might be helpful targets for medicine to struggle cognitive decline among the many aged, based on the study, revealed within the journal Nature.
Outside commentators mentioned the findings have been thrilling however a hearty dose of warning was wanted.
“The study shows that a human protein can reverse cognitive ageing in mice,” mentioned Jennifer Wild, a researcher in scientific psychology at Britain’s Oxford University.
“This does not mean that the protein can cure dementia or cognitive ageing in humans,” she instructed the London-based Science Media Centre (SMC).
Alzheimer’s specialists mentioned that the success with the lab mice touched on cognitive decline that comes naturally in ageing — and this can be a course of that’s completely different from dementia, which is brought on by illness.
“Although the treatments tested here boosted some aspects of learning and memory in mice, we don’t know how relevant the findings might be to people,” mentioned David Reynolds, chief scientific officer at Alzheimer’s Research UK.
“This research, while interesting, only looked at memory and thinking changes caused by ageing, and not those involved in dementia.”
Alzheimer’s illness is the most typical type of dementia, affecting some 47 million folks worldwide, and has no remedy and no efficient therapies. CBB
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